Version 5.4
Homo sapiens Protein: FAM123A
Summary
InnateDB Protein IDBP-478985.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM123A
Protein Name family with sequence similarity 123A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000426528
InnateDB Gene IDBG-16625 (FAM123A)
Protein Structure
UniProt Annotation
Function Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. {ECO:0000269PubMed:22128170}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:22128170}; Peripheral membrane protein {ECO:0000269PubMed:22128170}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process
GO:0007398 ectoderm development
GO:0016055 Wnt signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR019003 Uncharacterised protein family FAM123
PFAM PF09422
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N7J2
PhosphoSite PhosphoSite-Q8N7J2
TrEMBL Q8N785
UniProt Splice Variant
Entrez Gene 219287
UniGene Hs.731897
RefSeq NP_689917
HUGO HGNC:26360
OMIM 614659
CCDS CCDS53859
HPRD 08067
IMGT
EMBL AK055049 AK098343 AK098796 AL359757 BC032653 BC041392
GenPept AAH32653 AAH41392 BAB70845 BAC05288 BAC05414 CAH70807

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca