Version 5.4
Homo sapiens Protein: TMED4
Summary
InnateDB Protein IDBP-479066.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMED4
Protein Name transmembrane emp24 protein transport domain containing 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000417443
InnateDB Gene IDBG-14997 (TMED4)
Protein Structure
UniProt Annotation
Function Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
Biological Process
GO:0006810 transport
GO:0007165 signal transduction
GO:0015031 protein transport
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009038 GOLD
PFAM PF01105
PF13897
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z7H5
PhosphoSite PhosphoSite-Q7Z7H5
TrEMBL
UniProt Splice Variant
Entrez Gene 222068
UniGene Hs.598832
RefSeq
HUGO HGNC:22301
OMIM 612038
CCDS
HPRD 13666
IMGT
EMBL AB097009 AK074557 AK290125 AK294122 AY191223 BC052641 BC057851 BX647965 CH236960 CH471128
GenPept AAH52641 AAH57851 AAP20105 BAC11058 BAC77362 BAF82814 BAG57455 EAL23751 EAW61090 EAW61091

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca