InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HS3ST5

Summary

InnateDB Protein

IDBP-479073.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HS3ST5

Protein Name

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000427888

InnateDB Gene

IDBG-408918 (HS3ST5)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA- GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O- sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. {ECO:0000269PubMed:12138164}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle and fetal brain, and also found in adult brain, spinal cord, cerebellum and colon. {ECO:0000269PubMed:12138164, ECO:0000269PubMed:12740361}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008146	sulfotransferase activity
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006477	protein sulfation
GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO:0030203	glycosaminoglycan metabolic process
GO:0044281	small molecule metabolic process
GO:0046596	regulation of viral entry into host cell
GO:0050819	negative regulation of coagulation