Homo sapiens Protein: H2AFY | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-479110.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | H2AFY | ||||||||||||||||||||||
Protein Name | H2A histone family, member Y | ||||||||||||||||||||||
Synonyms | H2A.y; H2A/y; H2AF12M; H2AFJ; MACROH2A1.1; macroH2A1.2; mH2A1; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000423563 | ||||||||||||||||||||||
InnateDB Gene | IDBG-45483 (H2AFY) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP- ribose, and may be involved in ADP-ribose-mediated chromatin modulation. {ECO:0000269PubMed:12718888, ECO:0000269PubMed:15621527, ECO:0000269PubMed:15897469, ECO:0000269PubMed:16107708, ECO:0000269PubMed:16428466}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Ubiquitous. {ECO:0000269PubMed:9714746}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR002119
Histone H2A IPR002589 Macro domain IPR007125 Histone core IPR009072 Histone-fold IPR021171 Core histone macro-H2A |
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PFAM |
PF01661
PF00125 |
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PRINTS |
PR00620
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PIRSF |
PIRSF037942
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SMART |
SM00414
SM00506 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O75367 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O75367 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 9555 | ||||||||||||||||||||||
UniGene | Hs.737970 | ||||||||||||||||||||||
RefSeq | NP_613258 | ||||||||||||||||||||||
HUGO | HGNC:4740 | ||||||||||||||||||||||
OMIM | 610054 | ||||||||||||||||||||||
CCDS | CCDS4185 | ||||||||||||||||||||||
HPRD | 13624 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC026691 AF041483 AF044286 AF054174 AK023409 AY134746 BC013331 BC095406 | ||||||||||||||||||||||
GenPept | AAC33433 AAC33434 AAC39908 AAH13331 AAH95406 AAN08620 BAB14565 | ||||||||||||||||||||||