Version 5.4
Homo sapiens Protein: PTTG2
Summary
InnateDB Protein IDBP-479126.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTTG2
Protein Name pituitary tumor-transforming 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000424261
InnateDB Gene IDBG-409181 (PTTG2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors. {ECO:0000269PubMed:10084610, ECO:0000269PubMed:10806349}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0017124 SH3 domain binding
Biological Process
GO:0051276 chromosome organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006940 Securin sister-chromatid separation inhibitor
PFAM PF04856
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZH5
PhosphoSite PhosphoSite-Q9NZH5
TrEMBL
UniProt Splice Variant
Entrez Gene 10744
UniGene Hs.668806
RefSeq NP_006598
HUGO HGNC:9691
OMIM 604231
CCDS CCDS54755
HPRD 09176
IMGT
EMBL AC021106 AF095288 AF116538 AF200719 BC069114 BC069400
GenPept AAC64410 AAD41262 AAF72579 AAH69114 AAH69400

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca