Version 5.4
Homo sapiens Protein: REPS2
Summary
InnateDB Protein IDBP-47935.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REPS2
Protein Name RALBP1 associated Eps domain containing 2
Synonyms POB1;
Species Homo sapiens
Ensembl Protein ENSP00000306033
InnateDB Gene IDBG-47929 (REPS2)
Protein Structure
UniProt Annotation
Function Involved in growth factor signaling through its influence on the Ral signaling pathway.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Relatively highly expressed in androgen-dependent as compared to androgen-independent prostate cancer cell lines and xenografts. Isoform 2 is down-regulated during progression of prostate cancer.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000261 EPS15 homology (EH)
IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00027
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFH8
PhosphoSite PhosphoSite-Q8NFH8
TrEMBL
UniProt Splice Variant
Entrez Gene 9185
UniGene Hs.186810
RefSeq NP_001074444
HUGO HGNC:9963
OMIM 300317
CCDS CCDS43919
HPRD 02262
IMGT
EMBL AF010233 AF511533 AF512951 AL732371 AL929302
GenPept AAC02901 AAM43933 AAM43953 CAI40017 CAI41286 CAO03550 CAO03570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca