InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNF8

Summary

InnateDB Protein

IDBP-479467.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNF8

Protein Name

SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)

Synonyms

Dot3; EAP30; VPS22;

Species

Homo sapiens

Ensembl Protein

ENSP00000421380

InnateDB Gene

IDBG-57369 (SNF8)

Protein Structure

UniProt Annotation

Function

Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. {ECO:0000269PubMed:17714434, ECO:0000269PubMed:17959629, ECO:0000269PubMed:18031739}.

Subcellular Localization

Cytoplasm. Endosome membrane. Nucleus {ECO:0000305}. Late endosome membrane. Note=Recruited to the endosome membrane to participate in vesicle formation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:0061024	membrane organization