InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCEA1

Summary

InnateDB Protein

IDBP-479542.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCEA1

Protein Name

transcription elongation factor A (SII), 1

Synonyms

GTF2S; SII; TCEA; TF2S; TFIIS;

Species

Homo sapiens

Ensembl Protein

ENSP00000428426

InnateDB Gene

IDBG-21879 (TCEA1)

Protein Structure

UniProt Annotation

Function

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Subcellular Localization

Nucleus.

Disease Associations

Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0016032	viral process
GO:0030218	erythrocyte differentiation
GO:0032784	regulation of DNA-templated transcription, elongation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR001222 Zinc finger, TFIIS-type
IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
IPR003618 Transcription elongation factor S-II, central domain
IPR006289 Transcription elongation factor, TFIIS
IPR016492 Transcription elongation factor, TFIIS-related
IPR017890 Transcription elongation factor S-IIM
IPR017923 Transcription factor IIS, N-terminal

PFAM

PF01096
PF07500
PF08711

PRINTS

PIRSF

PIRSF006704

SMART

SM00440
SM00509
SM00510

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt