Version 5.4
Homo sapiens Protein: GLYATL2
Summary
InnateDB Protein IDBP-47972.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLYATL2
Protein Name glycine-N-acyltransferase-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000287275
InnateDB Gene IDBG-47970 (GLYATL2)
Protein Structure
UniProt Annotation
Function Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0- CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine. {ECO:0000269PubMed:20305126}.
Subcellular Localization Endoplasmic reticulum {ECO:0000269PubMed:20305126}.
Disease Associations
Tissue Specificity Expressed at highest levels in salivary gland and trachea. Also detected in thyroid gland, spinal cord, prostate, lung and fetal brain. {ECO:0000269PubMed:20305126}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0047961 glycine N-acyltransferase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR013652 Glycine N-acyltransferase, C-terminal
IPR013653 FR47-like
IPR015938 Glycine N-acyltransferase, N-terminal
IPR016181 Acyl-CoA N-acyltransferase
PFAM PF08444
PF08445
PF06021
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WU03
PhosphoSite PhosphoSite-Q8WU03
TrEMBL A0A024R4Z5
UniProt Splice Variant
Entrez Gene 219970
UniGene Hs.254271
RefSeq NP_659453
HUGO HGNC:24178
OMIM 614762
CCDS CCDS41649
HPRD 16568
IMGT
EMBL AB207211 AF426250 BC016789 BC021682 CH471076
GenPept AAH16789 AAH21682 AAO73139 BAF63415 EAW73826 EAW73827

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca