InnateDB Protein
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IDBP-479755.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SPINK13
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Protein Name
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serine peptidase inhibitor, Kazal type 13 (putative)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000421048
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InnateDB Gene
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IDBG-233048 (SPINK13)
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Protein Structure
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Function |
May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from premature reaction (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000250}. Note=Secreted into the lumen of the initial segment of the epididymis and binds to sperm. In the initial segment of epididymis, localizes on the dorsal surface of the acrosomal region of sperm, gradually becomes more restricted to the acrosomal region in spermatozoa during epididymal transit (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004867
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serine-type endopeptidase inhibitor activity
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GO:0005515
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protein binding
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Biological Process |
GO:0010951
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negative regulation of endopeptidase activity
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GO:1902225
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negative regulation of acrosome reaction
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Cellular Component |
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PDB ID |
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InterPro |
IPR002350
Kazal domain
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PFAM |
PF00050
PF07648
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PRINTS |
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PIRSF |
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SMART |
SM00280
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TIGRFAMs |
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Modification |
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SwissProt |
Q1W4C9
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PhosphoSite |
PhosphoSite-Q1W4C9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
153218
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UniGene |
Hs.483771
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RefSeq |
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HUGO |
HGNC:27200
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OMIM |
615205
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CCDS |
CCDS43383
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HPRD |
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IMGT |
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EMBL |
BC128163
BC128164
CH471062
DQ438947
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GenPept |
AAI28164
AAI28165
ABD96086
EAW61812
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