Version 5.4
Homo sapiens Protein: AHRR
Summary
InnateDB Protein IDBP-479807.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AHRR
Protein Name aryl-hydrocarbon receptor repressor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000424601
InnateDB Gene IDBG-10192 (AHRR)
Protein Structure
UniProt Annotation
Function Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269PubMed:17890447, ECO:0000269PubMed:18172554}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17980155}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:17980155}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
Disease Associations
Tissue Specificity Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. {ECO:0000269PubMed:11835227, ECO:0000269PubMed:14672759, ECO:0000269PubMed:18172554}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004871 signal transducer activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000014 PAS domain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767 PAS fold
PFAM PF13188
PF13426
PF00010
PF00989
PRINTS
PIRSF
SMART SM00091
SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A9YTQ3
PhosphoSite PhosphoSite-A9YTQ3
TrEMBL E5RGQ2
UniProt Splice Variant
Entrez Gene 57491
UniGene
RefSeq NP_001229341
HUGO HGNC:346
OMIM 606517
CCDS CCDS56355
HPRD 07356
IMGT
EMBL AB033060 AC010442 AC118458 AF293629 AF293630 AF293631 AF293632 AF293633 AF293634 AF293635 AF293636 AF293637 AF293638 AF293639 BC151852 BC152406 CH471235 EU293605
GenPept AAG33381 AAI51853 AAI52407 ABX89616 BAA86548 EAW50992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca