Version 5.4
Homo sapiens Protein: MCIN
Summary
InnateDB Protein IDBP-479950.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCIN
Protein Name Protein Idas
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000426359
InnateDB Gene IDBG-300508 (MCIN)
Protein Structure
UniProt Annotation
Function Transcription regulator required for multiciliate cell differentiation. Acts by promoting transcription of genes required for multiciliate cell formation. Probably acts in a multiprotein complex (By similarity). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. {ECO:0000250, ECO:0000269PubMed:21543332, ECO:0000269PubMed:24064211}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21543332}. Note=Excluded from the nucleolus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006275 regulation of DNA replication
GO:0006351 transcription, DNA-templated
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0042384 cilium assembly
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR022786 Geminin/Multicilin
PFAM PF07412
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt D6RGH6
PhosphoSite PhosphoSite-D6RGH6
TrEMBL
UniProt Splice Variant
Entrez Gene 345643
UniGene Hs.394578
RefSeq NP_001177716
HUGO HGNC:40050
OMIM 614086
CCDS CCDS54853
HPRD
IMGT
EMBL AC091977 FR854393
GenPept CCA89438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca