InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEK1

Summary

InnateDB Protein

IDBP-479989.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEK1

Protein Name

NIMA (never in mitosis gene a)-related kinase 1

Synonyms

NY-REN-55; SRPS2; SRPS2A; SRTD6;

Species

Homo sapiens

Ensembl Protein

ENSP00000423332

InnateDB Gene

IDBG-44149 (NEK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0042384	cilium assembly

Cellular Component

GO:0000242	pericentriolar material
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt