InnateDB Protein
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IDBP-480020.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NREP
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Protein Name
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chromosome 5 open reading frame 13
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Synonyms
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C5orf13; D4S114; P311; PRO1873; PTZ17; SEZ17;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000422630
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InnateDB Gene
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IDBG-36834 (NREP)
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Protein Structure
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Function |
May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. {ECO:0000250, ECO:0000269PubMed:11358844, ECO:0000269PubMed:16229809}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11358844}.
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Disease Associations |
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Tissue Specificity |
Expressed in lung (at protein level). {ECO:0000269PubMed:16484684}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR024417
Neuronal protein 3.1
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PFAM |
PF11092
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16612
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PhosphoSite |
PhosphoSite-Q16612
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TrEMBL |
D6RIC9
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UniProt Splice Variant |
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Entrez Gene |
9315
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UniGene |
Hs.738960
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RefSeq |
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HUGO |
HGNC:16834
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OMIM |
607332
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CCDS |
CCDS4105
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HPRD |
09545
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IMGT |
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EMBL |
AC022108
AC025182
AC025450
AC114297
AK298779
AK315617
BC011050
BC019068
BC072013
BC072443
CH471086
U30521
U36189
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GenPept |
AAA74903
AAA93255
AAH11050
AAH19068
AAH72013
AAH72443
BAG37985
BAH12868
EAW49019
EAW49020
EAW49021
EAW49023
EAW49025
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