Version 5.4
Homo sapiens Protein: RSPO2
Summary
InnateDB Protein IDBP-480144.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RSPO2
Protein Name R-spondin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427937
InnateDB Gene IDBG-32363 (RSPO2)
Protein Structure
UniProt Annotation
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors. {ECO:0000269PubMed:21727895, ECO:0000269PubMed:21909076, ECO:0000269PubMed:22615920}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000884 Thrombospondin, type 1 repeat
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
PFAM PF00090
PRINTS
PIRSF
SMART SM00209
SM00261
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UXX9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 340419
UniGene Hs.444834
RefSeq NP_001269792
HUGO HGNC:28583
OMIM 610575
CCDS CCDS64953
HPRD 17536
IMGT
EMBL AC025508 AK123023 AP003479 AY358166 BC027938 BC036554 CH471060
GenPept AAH27938 AAH36554 AAQ88533 BAG53852 EAW91916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca