Version 5.4
Homo sapiens Protein: SH2D4A
Summary
InnateDB Protein IDBP-480157.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2D4A
Protein Name SH2 domain containing 4A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000428684
InnateDB Gene IDBG-9465 (SH2D4A)
Protein Structure
UniProt Annotation
Function Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. {ECO:0000269PubMed:18641339, ECO:0000269PubMed:19712589}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18641339}. Note=Located at podocyte foot processes. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Aberrantly expressed in some cancers. {ECO:0000269PubMed:12476414}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019902 phosphatase binding
Biological Process
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
PFAM PF00017
PF14633
PRINTS PR00401
PIRSF
SMART SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H788
PhosphoSite PhosphoSite-Q9H788
TrEMBL
UniProt Splice Variant
Entrez Gene 63898
UniGene Hs.303208
RefSeq NP_001167630
HUGO HGNC:26102
OMIM 614968
CCDS CCDS6009
HPRD 08340
IMGT
EMBL AC068880 AK024620 AK024799 AK293301 AY190323 BC014525 BC067117 BC082982
GenPept AAH14525 AAH67117 AAH82982 AAO41715 BAB14935 BAB15010 BAG56822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca