InnateDB Protein
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IDBP-480300.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS22
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Protein Name
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regulator of G-protein signaling 22
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000427798
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InnateDB Gene
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IDBG-30491 (RGS22)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:18703424}. Nucleus {ECO:0000269PubMed:18703424}. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.
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Disease Associations |
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Tissue Specificity |
Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level). {ECO:0000269PubMed:18703424}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NE09
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PhosphoSite |
PhosphoSite-Q8NE09
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TrEMBL |
E5RHE4
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UniProt Splice Variant |
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Entrez Gene |
26166
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UniGene |
Hs.120021
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RefSeq |
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HUGO |
HGNC:24499
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OMIM |
615650
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CCDS |
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HPRD |
13155
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IMGT |
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EMBL |
AC021590
AK292559
AL117544
AP005356
AY009106
BC036665
BC047060
BC092411
CH471060
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GenPept |
AAG49397
AAH36665
AAH47060
AAH92411
BAF85248
CAB55986
EAW91794
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