InnateDB Protein
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IDBP-480407.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PCBD2
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Protein Name
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pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000421544
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InnateDB Gene
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IDBG-45343 (PCBD2)
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Protein Structure
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Function |
Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). {ECO:0000250}.Regulates the dimerization of homeodomain protein HNF-1- alpha and enhances its transcriptional activity. {ECO:0000269PubMed:11980910}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004505
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phenylalanine 4-monooxygenase activity
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GO:0005515
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protein binding
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GO:0008124
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4-alpha-hydroxytetrahydrobiopterin dehydratase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001533
Transcriptional coactivator/pterin dehydratase
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PFAM |
PF01329
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H0N5
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PhosphoSite |
PhosphoSite-Q9H0N5
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TrEMBL |
H0YA52
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UniProt Splice Variant |
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Entrez Gene |
84105
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UniGene |
Hs.605360
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RefSeq |
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HUGO |
HGNC:24474
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OMIM |
609836
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CCDS |
CCDS43364
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HPRD |
17824
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IMGT |
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EMBL |
AC006077
AC008670
AF499009
AL136721
BC054021
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GenPept |
AAH54021
AAM18136
CAB66655
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