InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UNC13A

Summary

InnateDB Protein

IDBP-480580.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC13A

Protein Name

unc-13 homolog A (C. elegans)

Synonyms

Munc13-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000429562

InnateDB Gene

IDBG-36944 (UNC13A)

Protein Structure

UniProt Annotation

Function

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localized to the active zone of presynaptic density. Translocated to the plasma membrane as response to phorbol ester binding (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in pancreatic islet cells. {ECO:0000269PubMed:12871971}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0001956	positive regulation of neurotransmitter secretion
GO:0007268	synaptic transmission
GO:0007528	neuromuscular junction development
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016188	synaptic vesicle maturation
GO:0035249	synaptic transmission, glutamatergic
GO:0035556	intracellular signal transduction
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0050435	beta-amyloid metabolic process
GO:0060384	innervation

Cellular Component

GO:0005737	cytoplasm
GO:0030054	cell junction
GO:0030424	axon
GO:0031594	neuromuscular junction
GO:0042734	presynaptic membrane
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR010439 Calcium-dependent secretion activator
IPR019558 Mammalian uncoordinated homology 13, subgroup, domain 2

PFAM

PF00168
PF00130
PF06292
PF10540

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt