Version 5.4
Homo sapiens Protein: LYRM4
Summary
InnateDB Protein IDBP-480621.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYRM4
Protein Name LYR motif containing 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418787
InnateDB Gene IDBG-235091 (LYRM4)
Protein Structure
UniProt Annotation
Function Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. {ECO:0000269PubMed:17331979, ECO:0000269PubMed:19454487}.
Subcellular Localization Mitochondrion. Nucleus.
Disease Associations Combined oxidative phosphorylation deficiency 19 (COXPD19) [MIM:615595]: A mitochondrial disorder characterized by respiratory distress, hypotonia, and severe lactic acidosis in the newborn period. Other features include gastroesophageal reflux and elevated liver enzymes with normal synthetic function. {ECO:0000269PubMed:23814038}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Reduced mRNA levels in Friedreich ataxia patients. {ECO:0000269PubMed:17331979}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR008011 Complex 1 LYR protein
PFAM PF05347
PF13232
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HD34
PhosphoSite PhosphoSite-Q9HD34
TrEMBL
UniProt Splice Variant
Entrez Gene 57128
UniGene Hs.387755
RefSeq NP_065141
HUGO HGNC:21365
OMIM 613311
CCDS CCDS4493
HPRD 12855
IMGT
EMBL AF170070 AF285118 AK291158 AL035653 AL121978 AL162381 BC009552
GenPept AAF25797 AAG01155 AAH09552 BAF83847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca