Version 5.4
Homo sapiens Protein: CEP70
Summary
InnateDB Protein IDBP-480760.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP70
Protein Name centrosomal protein 70kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419231
InnateDB Gene IDBG-58487 (CEP70)
Protein Structure
UniProt Annotation
Function Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:14654843, ECO:0000269PubMed:21795687}. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 63 [view]
Protein-Protein 63 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
PFAM PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHQ1
PhosphoSite PhosphoSite-Q8NHQ1
TrEMBL C9JZ04
UniProt Splice Variant
Entrez Gene 80321
UniGene Hs.701136
RefSeq XP_005247859
HUGO HGNC:29972
OMIM 614310
CCDS CCDS3102
HPRD 16779
IMGT
EMBL AC020890 AC022497 AC072045 AF202146 AF289495 AK023098 AK299003 AK301913 BC016050 BC030598 CH471052
GenPept AAG35616 AAG35791 AAH16050 AAH30598 BAB14403 BAH12924 BAH13584 EAW79062 EAW79063

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca