InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF131

Summary

InnateDB Protein

IDBP-480820.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF131

Protein Name

zinc finger protein 131

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000423945

InnateDB Gene

IDBG-19224 (ZNF131)

Protein Structure

UniProt Annotation

Function

Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269PubMed:18847501, ECO:0000269PubMed:22467880}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17306895, ECO:0000269PubMed:22467880, ECO:0000269PubMed:23404503}. Note=Sumoylation does not affect nuclear localization.

Disease Associations

Tissue Specificity

Predominant expression is found in different brain areas such as the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus. {ECO:0000269PubMed:12163020}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter