InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AZI2

Summary

InnateDB Protein

IDBP-481059.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AZI2

Protein Name

5-azacytidine induced 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419371

InnateDB Gene

IDBG-23171 (AZI2)

Protein Structure

UniProt Annotation

Function

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. {ECO:0000269PubMed:14560022, ECO:0000269PubMed:15611223, ECO:0000269PubMed:21931631}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14560022}.

Disease Associations

Tissue Specificity

Widely expressed. Abundant expression seen in the pancreas and testis. {ECO:0000269PubMed:14560022}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0001816	cytokine production
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0032607	interferon-alpha production
GO:0032609	interferon-gamma production
GO:0032635	interleukin-6 production
GO:0032640	tumor necrosis factor production
GO:0042110	T cell activation
GO:0044565	dendritic cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0097028	dendritic cell differentiation