InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FYB

Summary

InnateDB Protein

IDBP-481087.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FYB

Protein Name

FYN binding protein

Synonyms

ADAP; PRO0823; SLAP-130;

Species

Homo sapiens

Ensembl Protein

ENSP00000425845

InnateDB Gene

IDBG-17782 (FYB)

Protein Structure

UniProt Annotation

Function

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. {ECO:0000269PubMed:10747096, ECO:0000269PubMed:15849195, ECO:0000269PubMed:16980616}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9671755}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006607	NLS-bearing protein import into nucleus
GO:0006955	immune response
GO:0007165	signal transduction
GO:0008150	biological_process
GO:0035556	intracellular signal transduction
GO:0050852	T cell receptor signaling pathway