Version 5.4
Homo sapiens Protein: CEP97
Summary
InnateDB Protein IDBP-48112.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP97
Protein Name centrosomal protein 97kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000342510
InnateDB Gene IDBG-48110 (CEP97)
Protein Structure
UniProt Annotation
Function Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome. {ECO:0000269PubMed:17719545}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:17719545}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0030030 cell projection organization
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000048 IQ motif, EF-hand binding site
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00612
PRINTS
PIRSF
SMART SM00015
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IW35
PhosphoSite PhosphoSite-Q8IW35
TrEMBL
UniProt Splice Variant
Entrez Gene 79598
UniGene Hs.444135
RefSeq NP_078824
HUGO HGNC:26244
OMIM 615864
CCDS CCDS2944
HPRD 08014
IMGT
EMBL AC084198 AK026700 AK093100 BC041085
GenPept AAH41085 BAB15531 BAC04055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca