Version 5.4
Homo sapiens Protein: GIMAP5
Summary
InnateDB Protein IDBP-48122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GIMAP5
Protein Name GTPase, IMAP family member 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351473
InnateDB Gene IDBG-48120 (GIMAP5)
Protein Structure
UniProt Annotation
Function Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome {ECO:0000269PubMed:14724691, ECO:0000269PubMed:21487483}.
Disease Associations
Tissue Specificity Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T- cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms. {ECO:0000269PubMed:14724691}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006703 AIG1
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF04548
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96F15
PhosphoSite PhosphoSite-Q96F15
TrEMBL
UniProt Splice Variant
Entrez Gene 55340
UniGene
RefSeq NP_060854
HUGO HGNC:18005
OMIM 608086
CCDS CCDS5907
HPRD 16280
IMGT
EMBL AK002158 AK055568 BC011732 CH471173 CR457280
GenPept AAH11732 BAA92115 BAB70958 CAG33561 EAW54092 EAW54093 EAW54094

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca