InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCM4

Summary

InnateDB Protein

IDBP-481343.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM4

Protein Name

minichromosome maintenance complex component 4

Synonyms

CDC21; CDC54; hCdc21; NKCD; NKGCD; P1-CDC21;

Species

Homo sapiens

Ensembl Protein

ENSP00000430194

InnateDB Gene

IDBG-21089 (MCM4)

Protein Structure

UniProt Annotation

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269PubMed:9305914}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Natural killer cell and glucocorticoid deficiency with DNA repair defect (NKGCD) [MIM:609981]: An autosomal recessive disorder characterized by severe intra- and extrauterine growth retardation, microcephaly, decreased numbers of natural killer cells, and recurrent viral infections, most often affecting the respiratory tract and leading to respiratory failure. Affected individuals also have adrenal insufficiency requiring corticosteroid replacement therapy and may have an increased susceptibility to cancer. {ECO:0000269PubMed:22354167, ECO:0000269PubMed:22354170, ECO:0000269PubMed:22499342}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	97 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0016887	ATPase activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016020	membrane
GO:0042555	MCM complex

Protein Structure and Domains

PDB ID

InterPro

IPR000523 Magnesium chelatase, ChlI subunit
IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
IPR008047 Mini-chromosome maintenance complex protein 4
IPR011703 ATPase, AAA-3
IPR011704 ATPase, dynein-related, AAA domain
IPR012340 Nucleic acid-binding, OB-fold
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01078
PF00493
PF07726
PF07728

PRINTS

PR01657
PR01660

PIRSF

SMART

SM00350

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt