InnateDB Protein
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IDBP-481471.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RAD17
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Protein Name
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RAD17 homolog (S. pombe)
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Synonyms
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CCYC; HRAD17; R24L; RAD17SP; RAD24;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000427743
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InnateDB Gene
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IDBG-25785 (RAD17)
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Protein Structure
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Function |
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. {ECO:0000269PubMed:10208430, ECO:0000269PubMed:11418864, ECO:0000269PubMed:11687627, ECO:0000269PubMed:11799063, ECO:0000269PubMed:12578958, ECO:0000269PubMed:12672690, ECO:0000269PubMed:14500819, ECO:0000269PubMed:14624239, ECO:0000269PubMed:15235112, ECO:0000269PubMed:15538388, ECO:0000269PubMed:21659603}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10232579, ECO:0000269PubMed:10593953, ECO:0000269PubMed:11799063, ECO:0000269PubMed:12400013}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
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Disease Associations |
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Tissue Specificity |
Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors). {ECO:0000269PubMed:10208430, ECO:0000269PubMed:10232579, ECO:0000269PubMed:10480350, ECO:0000269PubMed:11602352, ECO:0000269PubMed:9660800}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
54
[view]
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Protein-Protein |
53
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018324
Checkpoint protein Rad24, fungi/metazoa
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75943
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PhosphoSite |
PhosphoSite-O75943
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TrEMBL |
D6RHU1
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UniProt Splice Variant |
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Entrez Gene |
5884
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UniGene |
Hs.739163
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RefSeq |
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HUGO |
HGNC:9807
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OMIM |
603139
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CCDS |
CCDS47226
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HPRD |
09124
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IMGT |
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EMBL |
AC145132
AC145146
AF017748
AF076838
AF085736
AF098533
AF098534
AF112263
AF126424
AJ001642
AJ004977
AJ131296
AJ131297
AJ131298
AJ131299
AJ131300
AJ131301
AJ131302
AJ131303
AJ131304
AJ131305
AJ131306
AJ131307
AJ131308
AK292487
AL122068
AY612854
BC032304
BX537441
CH471137
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GenPept |
AAC36334
AAC95520
AAC97950
AAC97951
AAD01620
AAD17334
AAD38878
AAH32304
AAT09763
BAF85176
CAA04894
CAA06251
CAB46364
CAB59244
CAD97683
EAW51283
EAW51284
EAW51285
EAW51286
EAW51288
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