Version 5.4
Homo sapiens Protein: KRT28
Summary
InnateDB Protein IDBP-48150.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT28
Protein Name keratin 28
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305263
InnateDB Gene IDBG-48146 (KRT28)
Protein Structure
UniProt Annotation
Function Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). {ECO:0000250UniProtKB:A6BLY7}.
Subcellular Localization Cytoplasm {ECO:0000250UniProtKB:A6BLY7}.
Disease Associations
Tissue Specificity Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level). {ECO:0000269PubMed:15617563, ECO:0000269PubMed:16874310}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005198 structural molecule activity
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005882 intermediate filament
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR002957 Keratin, type I
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01248
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z3Y7
PhosphoSite PhosphoSite-Q7Z3Y7
TrEMBL
UniProt Splice Variant
Entrez Gene 162605
UniGene Hs.59736
RefSeq NP_853513
HUGO HGNC:30842
OMIM
CCDS CCDS11376
HPRD 17245
IMGT
EMBL AC090283 AJ564207 AK129827
GenPept BAC85240 CAD91907

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca