InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ETFDH

Summary

InnateDB Protein

IDBP-481677.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETFDH

Protein Name

electron-transferring-flavoprotein dehydrogenase

Synonyms

ETFQO; MADD;

Species

Homo sapiens

Ensembl Protein

ENSP00000426638

InnateDB Gene

IDBG-42940 (ETFDH)

Protein Structure

UniProt Annotation

Function

Accepts electrons from ETF and reduces ubiquinone.

Subcellular Localization

Mitochondrion inner membrane.

Disease Associations

Glutaric aciduria 2C (GA2C) [MIM:231680]: An autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0043783	oxidoreductase activity, oxidizing metal ions with flavin as acceptor
GO:0046872	metal ion binding
GO:0048038	quinone binding
GO:0048039	ubiquinone binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006979	response to oxidative stress
GO:0022900	electron transport chain
GO:0022904	respiratory electron transport chain
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0031305	integral component of mitochondrial inner membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR003953 FAD binding domain
IPR007859 Electron transfer flavoprotein-ubiquinone oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00890
PF05187
PF07992

PRINTS

PR00469

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16134