Version 5.4
Homo sapiens Protein: CXXC5
Summary
InnateDB Protein IDBP-481759.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXXC5
Protein Name CXXC finger protein 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427379
InnateDB Gene IDBG-47953 (CXXC5)
Protein Structure
UniProt Annotation
Function May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. {ECO:0000250, ECO:0000269PubMed:19182210, ECO:0000269PubMed:19557330}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19182210, ECO:0000269PubMed:19557330}. Cytoplasm {ECO:0000250}. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004871 signal transducer activity
GO:0008270 zinc ion binding
Biological Process
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR002857 Zinc finger, CXXC-type
PFAM PF02008
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7LFL8
PhosphoSite PhosphoSite-Q7LFL8
TrEMBL E7EVI8
UniProt Splice Variant
Entrez Gene 51523
UniGene Hs.740473
RefSeq
HUGO HGNC:26943
OMIM 612752
CCDS CCDS43370
HPRD 13105
IMGT
EMBL AB097005 AB097032 AC113361 AF151029 AK001782 AK024338 AY007103 BC002490 BC006428 BC017439 BC024040 BC041013 CH471062 GQ379202
GenPept AAF36115 AAG01986 AAH02490 AAH06428 AAH17439 AAH24040 AAH41013 ACU80469 BAA91907 BAC77358 BAC77385 BAG51292 EAW62090 EAW62091 EAW62092 EAW62093

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca