Version 5.4
Homo sapiens Protein: ZFP42
Summary
InnateDB Protein IDBP-481907.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFP42
Protein Name zinc finger protein 42 homolog (mouse)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000424662
InnateDB Gene IDBG-47867 (ZFP42)
Protein Structure
UniProt Annotation
Function Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines. {ECO:0000269PubMed:12110702, ECO:0000269PubMed:16344273, ECO:0000269PubMed:16424014, ECO:0000269PubMed:16865673}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007126 meiotic nuclear division
GO:0008584 male gonad development
GO:0008585 female gonad development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96MM3
PhosphoSite PhosphoSite-Q96MM3
TrEMBL
UniProt Splice Variant
Entrez Gene 132625
UniGene Hs.335787
RefSeq
HUGO HGNC:30949
OMIM 614572
CCDS CCDS3849
HPRD 15726
IMGT
EMBL AC108073 AF450454 AK056719 AY429593 CH471056
GenPept AAL47167 AAR07993 BAB71264 EAX04610 EAX04611 EAX04612

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca