InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUB1

Summary

InnateDB Protein

IDBP-481990.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUB1

Protein Name

SUB1 homolog (S. cerevisiae)

Synonyms

p14; P15; PC4;

Species

Homo sapiens

Ensembl Protein

ENSP00000426850

InnateDB Gene

IDBG-14687 (SUB1)

Protein Structure

UniProt Annotation

Function

General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). {ECO:0000269PubMed:16605275, ECO:0000269PubMed:16689930, ECO:0000269PubMed:7628453, ECO:0000269PubMed:8062391, ECO:0000269PubMed:8062392, ECO:0000269PubMed:9360603, ECO:0000269PubMed:9482861}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	39 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter