Version 5.4
Homo sapiens Protein: VDAC3
Summary
InnateDB Protein IDBP-482316.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VDAC3
Protein Name voltage-dependent anion channel 3
Synonyms HD-VDAC3; VDAC-3;
Species Homo sapiens
Ensembl Protein ENSP00000428845
InnateDB Gene IDBG-20244 (VDAC3)
Protein Structure
UniProt Annotation
Function Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. {ECO:0000250}.
Subcellular Localization Mitochondrion outer membrane.
Disease Associations
Tissue Specificity Widely expressed. Highest in testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity
Biological Process
GO:0006820 anion transport
GO:0015853 adenine transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001925 Porin, eukaryotic type
IPR027246 Eukaryotic porin/Tom40
PFAM PF01459
PRINTS PR00185
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y277
PhosphoSite PhosphoSite-Q9Y277
TrEMBL
UniProt Splice Variant
Entrez Gene 7419
UniGene
RefSeq NP_001129166
HUGO HGNC:12674
OMIM 610029
CCDS CCDS47850
HPRD 06750
IMGT
EMBL AF038962 AH008073 BC056870 U90943
GenPept AAB93872 AAC39876 AAD49610 AAH56870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca