InnateDB Protein
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IDBP-482352.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AGGF1
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Protein Name
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angiogenic factor with G patch and FHA domains 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000424733
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InnateDB Gene
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IDBG-29861 (AGGF1)
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Protein Structure
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Function |
Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269PubMed:14961121}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:14961121}. Secreted {ECO:0000269PubMed:14961121}. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted.
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Disease Associations |
Klippel-Trenaunay syndrome (KTS) [MIM:149000]: Congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. {ECO:0000269PubMed:14961121}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed. Expressed in endothelial cells, vascular smooth muscle cells and osteoblasts. Expressed in umbilical vein endothelial cells and microvascular endothelial cells. {ECO:0000269PubMed:14961121}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N302
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PhosphoSite |
PhosphoSite-Q8N302
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55109
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UniGene |
Hs.653659
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RefSeq |
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HUGO |
HGNC:24684
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OMIM |
608464
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CCDS |
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HPRD |
07621
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IMGT |
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EMBL |
AK001145
AY500994
AY500996
BC002828
BC029382
U84971
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GenPept |
AAB60856
AAH02828
AAH29382
AAR97615
AAR97617
BAA91519
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