InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLIT3

Summary

InnateDB Protein

IDBP-482369.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLIT3

Protein Name

slit homolog 3 (Drosophila)

Synonyms

MEGF5; SLIL2; Slit-3; SLIT1; slit2;

Species

Homo sapiens

Ensembl Protein

ENSP00000430333

InnateDB Gene

IDBG-56989 (SLIT3)

Protein Structure

UniProt Annotation

Function

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in thyroid. {ECO:0000269PubMed:9813312}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0048495	Roundabout binding

Biological Process

GO:0007411	axon guidance
GO:0030308	negative regulation of cell growth
GO:0032870	cellular response to hormone stimulus
GO:0035385	Roundabout signaling pathway
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0051414	response to cortisol
GO:0061364	apoptotic process involved in luteolysis
GO:0070100	negative regulation of chemokine-mediated signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000742 Epidermal growth factor-like domain
IPR001611 Leucine-rich repeat
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR003591 Leucine-rich repeat, typical subtype
IPR006207 Cystine knot, C-terminal
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM