InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFKBIZ

Summary

InnateDB Protein

IDBP-48256.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFKBIZ

Protein Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325663

InnateDB Gene

IDBG-48252 (NFKBIZ)

Protein Structure

UniProt Annotation

Function

Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16513645}. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.

Disease Associations

Tissue Specificity

Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. {ECO:0000269PubMed:16513645}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006954	inflammatory response
GO:0045087	innate immune response (InnateDB)