InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUSP7

Summary

InnateDB Protein

IDBP-482583.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP7

Protein Name

dual specificity phosphatase 7

Synonyms

MKPX; PYST2;

Species

Homo sapiens

Ensembl Protein

ENSP00000417183

InnateDB Gene

IDBG-38157 (DUSP7)

Protein Structure

UniProt Annotation

Function

Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors. {ECO:0000269PubMed:14603440}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells. {ECO:0000269PubMed:14576828}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051403	stress-activated MAPK cascade

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR001763 Rhodanese-like domain
IPR008343 Mitogen-activated protein (MAP) kinase phosphatase
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782
PF00581

PRINTS

PR01764

PIRSF

PIRSF000939

SMART

SM00450
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References