InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CIAO1

Summary

InnateDB Protein

IDBP-482590.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CIAO1

Protein Name

cytosolic iron-sulfur protein assembly 1

Synonyms

CIA1; WDR39;

Species

Homo sapiens

Ensembl Protein

ENSP00000418287

InnateDB Gene

IDBG-61576 (CIAO1)

Protein Structure

UniProt Annotation

Function

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000255HAMAP-Rule:MF_03037, ECO:0000269PubMed:17937914, ECO:0000269PubMed:20797633}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	80 [view]
Protein-Protein	77 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007059	chromosome segregation
GO:0008284	positive regulation of cell proliferation
GO:0016226	iron-sulfur cluster assembly
GO:0044281	small molecule metabolic process