InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGAP3

Summary

InnateDB Protein

IDBP-482593.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGAP3

Protein Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418016

InnateDB Gene

IDBG-49238 (AGAP3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007264	small GTPase mediated signal transduction
GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001164 Arf GTPase activating protein
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01412
PF00169
PF00023
PF13606
PF11929
PF12796

PRINTS

PR00405
PR01415

PIRSF

SMART

SM00105
SM00233
SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt