InnateDB Protein
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IDBP-482637.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SNCB
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Protein Name
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synuclein, beta
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000424073
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InnateDB Gene
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IDBG-59051 (SNCB)
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Protein Structure
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Function |
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
|
Protein-Protein |
15
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0043086
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negative regulation of catalytic activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR001058
Synuclein
IPR002461
Beta-synuclein
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PFAM |
PF01387
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PRINTS |
PR01211
PR01213
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16143
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PhosphoSite |
PhosphoSite-Q16143
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TrEMBL |
A0A024R7R3
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UniProt Splice Variant |
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Entrez Gene |
6620
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UniGene |
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RefSeq |
XP_006714977
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HUGO |
HGNC:11140
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OMIM |
602569
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CCDS |
CCDS4406
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HPRD |
03980
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IMGT |
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EMBL |
AF053134
AF053135
AF053136
BC002902
BT006627
CH471195
CR457027
S69965
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GenPept |
AAB30860
AAC80286
AAH02902
AAP35273
CAG33308
EAW85063
EAW85064
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