Homo sapiens Protein: RAB21 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-48265.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | RAB21 | ||||||||||||||||||||||
Protein Name | RAB21, member RAS oncogene family | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000261263 | ||||||||||||||||||||||
InnateDB Gene | IDBG-48263 (RAB21) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. {ECO:0000250, ECO:0000269PubMed:18804435}. | ||||||||||||||||||||||
Subcellular Localization | Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid- telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression. {ECO:0000269PubMed:10887961}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000795
Elongation factor, GTP-binding domain IPR001806 Small GTPase superfamily IPR002041 Ran GTPase IPR003578 Small GTPase superfamily, Rho type IPR003579 Small GTPase superfamily, Rab type IPR005225 Small GTP-binding protein domain IPR006689 Small GTPase superfamily, ARF/SAR type IPR006762 Gtr1/RagA G protein IPR013684 Mitochondrial Rho-like IPR020849 Small GTPase superfamily, Ras type IPR027417 P-loop containing nucleoside triphosphate hydrolase |
||||||||||||||||||||||
PFAM |
PF00009
PF00071 PF00025 PF04670 PF08477 |
||||||||||||||||||||||
PRINTS |
PR00315
PR00449 PR00627 PR00328 |
||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00176
SM00174 SM00175 SM00173 |
||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9UL25 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UL25 | ||||||||||||||||||||||
TrEMBL | Q96GX3 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 23011 | ||||||||||||||||||||||
UniGene | Hs.735441 | ||||||||||||||||||||||
RefSeq | NP_055814 | ||||||||||||||||||||||
HUGO | HGNC:18263 | ||||||||||||||||||||||
OMIM | 612398 | ||||||||||||||||||||||
CCDS | CCDS9003 | ||||||||||||||||||||||
HPRD | 06695 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF091035 BC009109 BC021901 BC092475 CH471054 D42087 | ||||||||||||||||||||||
GenPept | AAF00048 AAH09109 AAH21901 AAH92475 BAA07682 EAW97270 EAW97271 | ||||||||||||||||||||||