InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF148

Summary

InnateDB Protein

IDBP-482737.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF148

Protein Name

zinc finger protein 148

Synonyms

BERF-1; BFCOL1; HT-BETA; pHZ-52; ZBP-89; ZFP148;

Species

Homo sapiens

Ensembl Protein

ENSP00000419322

InnateDB Gene

IDBG-54018 (ZNF148)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006968	cellular defense response
GO:0010629	negative regulation of gene expression
GO:0021762	substantia nigra development
GO:0045892	negative regulation of transcription, DNA-templated