Version 5.4
Homo sapiens Protein: FRMPD2
Summary
InnateDB Protein IDBP-482756.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRMPD2
Protein Name FERM and PDZ domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000422446
InnateDB Gene IDBG-73374 (FRMPD2)
Protein Structure
UniProt Annotation
Function May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). {ECO:0000269PubMed:19706687}.
Subcellular Localization Cytoplasm {ECO:0000305}. Basolateral cell membrane {ECO:0000269PubMed:19706687}. Cell junction, tight junction {ECO:0000269PubMed:19706687}. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1.
Disease Associations
Tissue Specificity Expressed in epithelial cells. {ECO:0000269PubMed:19706687}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
Biological Process
GO:0070830 tight junction assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005923 tight junction
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q68DX3
PhosphoSite PhosphoSite-Q68DX3
TrEMBL
UniProt Splice Variant
Entrez Gene 728798
UniGene Hs.723926
RefSeq NP_001035977
HUGO HGNC:28572
OMIM 613323
CCDS
HPRD 17019
IMGT
EMBL AC013284 AC074325 AK123038 AK131386 AY491519 BC031614 BC073954 BC144635 BC144639 CR749241
GenPept AAH31614 AAH73954 AAI44636 AAI44640 AAS79660 BAC85520 BAD18537 CAH18097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca