InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYBL1

Summary

InnateDB Protein

IDBP-482802.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYBL1

Protein Name

v-myb myeloblastosis viral oncogene homolog (avian)-like 1

Synonyms

A-MYB; AMYB;

Species

Homo sapiens

Ensembl Protein

ENSP00000429633

InnateDB Gene

IDBG-23911 (MYBL1)

Protein Structure

UniProt Annotation

Function

Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001005 SANT/Myb domain
IPR009057 Homeodomain-like
IPR012642 Transcription regulator Wos2-domain
IPR015395 C-myb, C-terminal
IPR017877 Myb-like domain

PFAM

PF00249
PF07988
PF09316

PRINTS

PIRSF

SMART

SM00717

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P10243