InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EDNRA

Summary

InnateDB Protein

IDBP-482826.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDNRA

Protein Name

endothelin receptor type A

Synonyms

ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR;

Species

Homo sapiens

Ensembl Protein

ENSP00000427259

InnateDB Gene

IDBG-40278 (EDNRA)

Protein Structure

UniProt Annotation

Function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels. {ECO:0000269PubMed:8611157, ECO:0000269PubMed:9284755}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding

Biological Process

GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007585	respiratory gaseous exchange
GO:0008152	metabolic process
GO:0008217	regulation of blood pressure
GO:0008283	cell proliferation
GO:0014824	artery smooth muscle contraction
GO:0015758	glucose transport
GO:0042310	vasoconstriction
GO:0048484	enteric nervous system development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000499 Endothelin receptor family
IPR002175 Endothelin receptor A
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00366
PR00570

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25101