Version 5.4
Homo sapiens Protein: CLDN12
Summary
InnateDB Protein IDBP-483123.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN12
Protein Name claudin 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419053
InnateDB Gene IDBG-25851 (CLDN12)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.
Subcellular Localization Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
GO:0034329 cell junction assembly
GO:0045216 cell-cell junction organization
GO:0070830 tight junction assembly
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR013287 Claudin-12
PFAM
PRINTS PR01872
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56749
PhosphoSite PhosphoSite-P56749
TrEMBL C9J841
UniProt Splice Variant
Entrez Gene 9069
UniGene Hs.741070
RefSeq NP_001172001
HUGO HGNC:2034
OMIM 611232
CCDS CCDS5618
HPRD 13064
IMGT
EMBL AC002456 AC006153 AJ250713 AL136770 BC036754 BC068532 CH236949 CH471091
GenPept AAH36754 AAH68532 AAP22363 CAB60617 CAB66704 EAL24163 EAW76876 EAW76877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca