InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYC

Summary

InnateDB Protein

IDBP-483271.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYC

Protein Name

v-myc myelocytomatosis viral oncogene homolog (avian)

Synonyms

bHLHe39; c-Myc; MRTL; MYCC;

Species

Homo sapiens

Ensembl Protein

ENSP00000430235

InnateDB Gene

IDBG-35442 (MYC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1433 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	1436 [view]
Protein-Protein	597 [view]
Protein-DNA	734 [view]
Protein-RNA	1 [view]
DNA-DNA	104 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032403	protein complex binding
GO:0046983	protein dimerization activity
GO:0070491	repressing transcription factor binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006112	energy reserve metabolic process
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006879	cellular iron ion homeostasis
GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010332	response to gamma radiation
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0015671	oxygen transport
GO:0032204	regulation of telomere maintenance
GO:0032873	negative regulation of stress-activated MAPK cascade
GO:0034644	cellular response to UV
GO:0035690	cellular response to drug
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044346	fibroblast apoptotic process
GO:0045656	negative regulation of monocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048147	negative regulation of fibroblast proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051276	chromosome organization
GO:0051782	negative regulation of cell division
GO:0060070	canonical Wnt signaling pathway
GO:0070848	response to growth factor
GO:0090096	positive regulation of metanephric cap mesenchymal cell proliferation
GO:2000573	positive regulation of DNA biosynthetic process
GO:2001022	positive regulation of response to DNA damage stimulus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR002418 Transcription regulator Myc
IPR003327 Leucine zipper, Myc
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR012682 Transcription regulator Myc, N-terminal

PFAM

PF02344
PF00010
PF01056

PRINTS

PR00044

PIRSF

PIRSF001705

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References