InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SGK3

Summary

InnateDB Protein

IDBP-483291.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGK3

Protein Name

serum/glucocorticoid regulated kinase family, member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000429022

InnateDB Gene

IDBG-23987 (SGK3)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. {ECO:0000269PubMed:12054501, ECO:0000269PubMed:12397388, ECO:0000269PubMed:12590200, ECO:0000269PubMed:12632189, ECO:0000269PubMed:12634932, ECO:0000269PubMed:12650886, ECO:0000269PubMed:12911626, ECO:0000269PubMed:14706641, ECO:0000269PubMed:15040001, ECO:0000269PubMed:15044175, ECO:0000269PubMed:15319523, ECO:0000269PubMed:15496163, ECO:0000269PubMed:15737648, ECO:0000269PubMed:15845389, ECO:0000269PubMed:16036218, ECO:0000269PubMed:16888620, ECO:0000269PubMed:17167223, ECO:0000269PubMed:18005662, ECO:0000269PubMed:19293151, ECO:0000269PubMed:20511718, ECO:0000269PubMed:21865597}.

Subcellular Localization

Cytoplasmic vesicle {ECO:0000250}. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.

Disease Associations

Tissue Specificity

Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER- positive breast tumors than ER-negative breast tumors. {ECO:0000269PubMed:21084382}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015459	potassium channel regulator activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017080	sodium channel regulator activity
GO:0017081	chloride channel regulator activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001558	regulation of cell growth
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0030334	regulation of cell migration
GO:0034220	ion transmembrane transport
GO:0042127	regulation of cell proliferation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0055085	transmembrane transport

Cellular Component

GO:0005769	early endosome
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001683 Phox homologous domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00787
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00312
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt