InnateDB Protein
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IDBP-483309.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLK
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Protein Name
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polymerase (DNA directed) kappa
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000426853
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InnateDB Gene
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IDBG-29209 (POLK)
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Protein Structure
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Function |
DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. {ECO:0000269PubMed:10620008, ECO:0000269PubMed:11024016, ECO:0000269PubMed:12145297, ECO:0000269PubMed:12444249, ECO:0000269PubMed:12952891, ECO:0000269PubMed:14630940, ECO:0000269PubMed:15533436}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12414988}. Note=Detected throughout the nucleus and at replication foci.
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Disease Associations |
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Tissue Specificity |
Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. {ECO:0000269PubMed:10518552, ECO:0000269PubMed:10620008}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001126
DNA-repair protein, UmuC-like
IPR006642
Zinc finger, Rad18-type putative
IPR017963
DNA-repair protein, UmuC-like, N-terminal
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PFAM |
PF00817
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PRINTS |
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PIRSF |
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SMART |
SM00734
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBT6
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PhosphoSite |
PhosphoSite-Q9UBT6
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TrEMBL |
D6RDX9
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UniProt Splice Variant |
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Entrez Gene |
51426
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UniGene |
Hs.732105
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RefSeq |
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HUGO |
HGNC:9183
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OMIM |
605650
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CCDS |
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HPRD |
09291
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IMGT |
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EMBL |
AB027564
AB036934
AB036935
AC010245
AC026424
AC116341
AF163570
AF194973
AF315602
AF318313
AK091659
AK314610
AY273797
AY769929
AY769930
AY769931
AY769932
BC014955
BC050718
CH471084
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GenPept |
AAF02540
AAF23270
AAH14955
AAH50718
AAN15780
AAN15781
AAP12648
AAV80827
AAV80828
AAV80829
AAV80830
BAA86943
BAB58975
BAB58976
BAC03714
BAG37179
EAW95763
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